Antibiotic perseverance increases the risk of resistance development

Brandis, Gerrit; Larsson, Jimmy; Elf, Johan

Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2023

• DOI för Antibiotic perseverance increases the risk of resistance development
• Ladda ner fulltext (pdf) av Antibiotic perseverance increases the risk of resistance development

Evolution of Bacterial Interspecies Hybrids with Enlarged Chromosomes

Bartke, Katrin; Huseby, Douglas L; Brandis, Gerrit; Hughes, Diarmaid

Ingår i Genome Biology and Evolution, 2022

• DOI för Evolution of Bacterial Interspecies Hybrids with Enlarged Chromosomes
• Ladda ner fulltext (pdf) av Evolution of Bacterial Interspecies Hybrids with Enlarged Chromosomes

Positive Selection during Niche Adaptation Results in Large-Scale and Irreversible Rearrangement of Chromosomal Gene Order in Bacteria

Cao, Sha; Brandis, Gerrit; Huseby, Douglas L; Hughes, Diarmaid

Ingår i Molecular biology and evolution, 2022

• DOI för Positive Selection during Niche Adaptation Results in Large-Scale and Irreversible Rearrangement of Chromosomal Gene Order in Bacteria
• Ladda ner fulltext (pdf) av Positive Selection during Niche Adaptation Results in Large-Scale and Irreversible Rearrangement of Chromosomal Gene Order in Bacteria

Chromosomal Location Determines the Rate of Intrachromosomal Homologous Recombination in Salmonella

Garmendia, Eva; Brandis, Gerrit; Guy, Lionel; Cao, Sha et al.

Ingår i mBio, 2021

• DOI för Chromosomal Location Determines the Rate of Intrachromosomal Homologous Recombination in Salmonella
• Ladda ner fulltext (pdf) av Chromosomal Location Determines the Rate of Intrachromosomal Homologous Recombination in Salmonella

Expression of the qepA1 gene is induced under antibiotic exposure

Brandis, Gerrit; Gockel, Jonas; Garoff, Linnéa; Guy, Lionel et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 1433-1440, 2021

• DOI för Expression of the qepA1 gene is induced under antibiotic exposure
• Ladda ner fulltext (pdf) av Expression of the qepA1 gene is induced under antibiotic exposure

Genetic Architecture and Fitness of Bacterial Interspecies Hybrids

Bartke, Katrin; Garoff, Linnéa; Huseby, Douglas L; Brandis, Gerrit et al.

Ingår i Molecular biology and evolution, s. 1472-1481, 2021

• DOI för Genetic Architecture and Fitness of Bacterial Interspecies Hybrids
• Ladda ner fulltext (pdf) av Genetic Architecture and Fitness of Bacterial Interspecies Hybrids

Mutant RNA polymerase can reduce susceptibility to antibiotics via ppGpp-independent induction of a stringent-like response

Brandis, Gerrit; Granström, Susanna; Leber, Anna T.; Bartke, Katrin et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 606-615, 2021

• DOI för Mutant RNA polymerase can reduce susceptibility to antibiotics via ppGpp-independent induction of a stringent-like response
• Ladda ner fulltext (pdf) av Mutant RNA polymerase can reduce susceptibility to antibiotics via ppGpp-independent induction of a stringent-like response

Reconstructing the Evolutionary History of a Highly Conserved Operon Cluster in Gammaproteobacteria and Bacilli

Brandis, Gerrit

Ingår i Genome Biology and Evolution, 2021

• DOI för Reconstructing the Evolutionary History of a Highly Conserved Operon Cluster in Gammaproteobacteria and Bacilli
• Ladda ner fulltext (pdf) av Reconstructing the Evolutionary History of a Highly Conserved Operon Cluster in Gammaproteobacteria and Bacilli

Resistance/fitness trade-off is a barrier to the evolution of MarR inactivation mutants in Escherichia coli

Praski Alzrigat, Lisa; Huseby, Douglas L.; Brandis, Gerrit; Hughes, Diarmaid

Ingår i Journal of Antimicrobial Chemotherapy, s. 77-83, 2021

• DOI för Resistance/fitness trade-off is a barrier to the evolution of MarR inactivation mutants in Escherichia coli
• Ladda ner fulltext (pdf) av Resistance/fitness trade-off is a barrier to the evolution of MarR inactivation mutants in Escherichia coli

Antibiotic resistance by high-level intrinsic suppression of a frameshift mutation in an essential gene

Huseby, Douglas L; Brandis, Gerrit; Praski Alzrigat, Lisa; Hughes, Diarmaid

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 3185-3191, 2020

• DOI för Antibiotic resistance by high-level intrinsic suppression of a frameshift mutation in an essential gene
• Ladda ner fulltext (pdf) av Antibiotic resistance by high-level intrinsic suppression of a frameshift mutation in an essential gene

Population Bottlenecks Strongly Influence the Evolutionary Trajectory to Fluoroquinolone Resistance in Escherichia coli

Garoff, Linnéa; Pietsch, Franziska; Huseby, Douglas L; Lilja, Tua et al.

Ingår i Molecular biology and evolution, s. 1637-1646, 2020

• DOI för Population Bottlenecks Strongly Influence the Evolutionary Trajectory to Fluoroquinolone Resistance in Escherichia coli
• Ladda ner fulltext (pdf) av Population Bottlenecks Strongly Influence the Evolutionary Trajectory to Fluoroquinolone Resistance in Escherichia coli

The SNAP hypothesis: Chromosomal rearrangements could emerge from positive Selection during Niche Adaptation

Brandis, Gerrit; Hughes, Diarmaid

Ingår i PLOS Genetics, 2020

• DOI för The SNAP hypothesis: Chromosomal rearrangements could emerge from positive Selection during Niche Adaptation
• Ladda ner fulltext (pdf) av The SNAP hypothesis: Chromosomal rearrangements could emerge from positive Selection during Niche Adaptation

Measuring Homologous Recombination Rates between Chromosomal Locations in Salmonella

Brandis, Gerrit; Cao, Sha; Hughes, Diarmaid

Ingår i Bio-protocol, 2019

• DOI för Measuring Homologous Recombination Rates between Chromosomal Locations in Salmonella

Operon Concatenation Is an Ancient Feature That Restricts the Potential to Rearrange Bacterial Chromosomes

Brandis, Gerrit; Cao, Sha; Hughes, Diarmaid

Ingår i Molecular biology and evolution, s. 1990-2000, 2019

• DOI för Operon Concatenation Is an Ancient Feature That Restricts the Potential to Rearrange Bacterial Chromosomes
• Ladda ner fulltext (pdf) av Operon Concatenation Is an Ancient Feature That Restricts the Potential to Rearrange Bacterial Chromosomes

Co-evolution with recombination affects the stability of mobile genetic element insertions within gene families of Salmonella

Brandis, Gerrit; Cao, Sha; Hughes, Diarmaid

Ingår i Molecular Microbiology, s. 697-710, 2018

• DOI för Co-evolution with recombination affects the stability of mobile genetic element insertions within gene families of Salmonella
• Ladda ner fulltext (pdf) av Co-evolution with recombination affects the stability of mobile genetic element insertions within gene families of Salmonella

Mechanisms of fitness cost reduction for rifampicin-resistant strains with deletion or duplication mutations in rpoB.

Brandis, Gerrit; Hughes, Diarmaid

Ingår i Scientific Reports, 2018

• DOI för Mechanisms of fitness cost reduction for rifampicin-resistant strains with deletion or duplication mutations in rpoB.
• Ladda ner fulltext (pdf) av Mechanisms of fitness cost reduction for rifampicin-resistant strains with deletion or duplication mutations in rpoB.

Transcriptional Regulation Buffers Gene Dosage Effects on a Highly Expressed Operon in Salmonella

Garmendia, Eva; Brandis, Gerrit; Hughes, Diarmaid

Ingår i mBio, 2018

• DOI för Transcriptional Regulation Buffers Gene Dosage Effects on a Highly Expressed Operon in Salmonella
• Ladda ner fulltext (pdf) av Transcriptional Regulation Buffers Gene Dosage Effects on a Highly Expressed Operon in Salmonella

Alternative Evolutionary Pathways for Drug-Resistant Small Colony Variant Mutants in Staphylococcus aureus

Cao, Sha; Huseby, Douglas L; Brandis, Gerrit; Hughes, Diarmaid

Ingår i mBio, 2017

• DOI för Alternative Evolutionary Pathways for Drug-Resistant Small Colony Variant Mutants in Staphylococcus aureus
• Ladda ner fulltext (pdf) av Alternative Evolutionary Pathways for Drug-Resistant Small Colony Variant Mutants in Staphylococcus aureus

Ciprofloxacin selects for RNA polymerase mutations with pleiotropic antibiotic resistance effects

Pietsch, Franziska; Bergman, Jessica M.; Brandis, Gerrit; Marcusson, Linda L. et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 75-84, 2017

• DOI för Ciprofloxacin selects for RNA polymerase mutations with pleiotropic antibiotic resistance effects

Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli: Multiple Antibiotic-Resistance, Gram-Negative Bacteria, Multidrug Efflux Pump, Urinary-Tract-Infections, Fluoroquinolone Resistance, Quinolone Resistance, Mechanisms, Expression, Sequence, Soxs

Praski Alzrigat, Lisa; Huseby, Douglas L; Brandis, Gerrit; Hughes, Diarmaid

Ingår i Journal of Antimicrobial Chemotherapy, s. 3016-3024, 2017

• DOI för Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli: Multiple Antibiotic-Resistance, Gram-Negative Bacteria, Multidrug Efflux Pump, Urinary-Tract-Infections, Fluoroquinolone Resistance, Quinolone Resistance, Mechanisms, Expression, Sequence, Soxs
• Ladda ner fulltext (pdf) av Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli: Multiple Antibiotic-Resistance, Gram-Negative Bacteria, Multidrug Efflux Pump, Urinary-Tract-Infections, Fluoroquinolone Resistance, Quinolone Resistance, Mechanisms, Expression, Sequence, Soxs

Having your cake and eating it - Staphylococcus aureus small colony variants can evolve faster growth rate without losing their antibiotic resistance

Brandis, Gerrit; Cao, Sha; Huseby, Douglas L.; Hughes, Diarmaid

Ingår i MICROBIAL CELL, s. 275-277, 2017

• DOI för Having your cake and eating it - Staphylococcus aureus small colony variants can evolve faster growth rate without losing their antibiotic resistance
• Ladda ner fulltext (pdf) av Having your cake and eating it - Staphylococcus aureus small colony variants can evolve faster growth rate without losing their antibiotic resistance

Mutation supply and relative fitness shape the genotypes of ciprofloxacin-resistant Escherichia coli

Huseby, Douglas L.; Pietsch, Franziska; Brandis, Gerrit; Garoff, Linnéa et al.

Ingår i Molecular biology and evolution, s. 1029-1039, 2017

• DOI för Mutation supply and relative fitness shape the genotypes of ciprofloxacin-resistant Escherichia coli
• Ladda ner fulltext (pdf) av Mutation supply and relative fitness shape the genotypes of ciprofloxacin-resistant Escherichia coli

Autoregulation of the tufB operon in Salmonella

Brandis, Gerrit; Bergman, Jessica M.; Hughes, Diarmaid

Ingår i Molecular Microbiology, s. 1004-1016, 2016

• DOI för Autoregulation of the tufB operon in Salmonella

Evidence for the critical role of a secondary site rpoB mutation in the compensatory evolution and successful transmission of an MDR tuberculosis outbreak strain

Meftahi, Nedra; Namouchi, Amine; Mhenni, Besma; Brandis, Gerrit et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 324-332, 2016

• DOI för Evidence for the critical role of a secondary site rpoB mutation in the compensatory evolution and successful transmission of an MDR tuberculosis outbreak strain

The Selective Advantage of Synonymous Codon Usage Bias in Salmonella

Brandis, Gerrit; Hughes, Diarmaid

Ingår i PLOS Genetics, 2016

• DOI för The Selective Advantage of Synonymous Codon Usage Bias in Salmonella
• Ladda ner fulltext (pdf) av The Selective Advantage of Synonymous Codon Usage Bias in Salmonella

Comprehensive phenotypic characterization of rifampicin resistance mutations in Salmonella provides insight into the evolution of resistance in Mycobacterium tuberculosis

Brandis, Gerrit; Pietsch, Franziska; Alemayehu, Rahel; Hughes, Diarmaid

Ingår i Journal of Antimicrobial Chemotherapy, s. 680-685, 2015

• DOI för Comprehensive phenotypic characterization of rifampicin resistance mutations in Salmonella provides insight into the evolution of resistance in Mycobacterium tuberculosis

Genetic characterization of compensatory evolution in strains carrying rpoB Ser531Leu, the rifampicin resistance mutation most frequently found in clinical isolates

Brandis, Gerrit; Hughes, Diarmaid

Ingår i Journal of Antimicrobial Chemotherapy, s. 2493-2497, 2013

• DOI för Genetic characterization of compensatory evolution in strains carrying rpoB Ser531Leu, the rifampicin resistance mutation most frequently found in clinical isolates

Fitness-compensatory mutations in rifampicin-resistant RNA polymerase

Brandis, Gerrit; Wrande, Marie; Liljas, Lars; Hughes, Diarmaid

Ingår i Molecular Microbiology, s. 142-151, 2012

• DOI för Fitness-compensatory mutations in rifampicin-resistant RNA polymerase

IncP-1β plasmids of Comamonas sp. and Delftia sp. strains isolated from a wastewater treatment plant mediate resistance to and decolorization of the triphenylmethane dye crystal violet

Stolze, Yvonne; Eikmeyer, Felix; Wibberg, Daniel; Brandis, Gerrit et al.

Ingår i Microbiology, s. 2060-2072, 2012

• DOI för IncP-1β plasmids of Comamonas sp. and Delftia sp. strains isolated from a wastewater treatment plant mediate resistance to and decolorization of the triphenylmethane dye crystal violet